Identification of endocrine-disrupting chemicals targeting key OP-associated genes via bioinformatics and machine learning

Osteoporosis (OP), a metabolic disorder predominantly impacting postmenopausal women, has seen considerable progress in diagnosis and treatment over the past few decades.However, the intricate interplay between genetic factors and endocrine disruptors (EDCs) in the pathogenesis of OP remains inadequately elucidated.The objective of this research is

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On the Stability of Eccentrically Compressed Reinforced Concrete Elements with a Small Eccentricity, Taking into Account the Rheological Properties of Concrete

In the practice of modern construction, flexible centrally and eccentrically compressed reinforced read more concrete elements are becoming more common.In this regard, the relevance of studying their work and the mechanism of bearing capacity exhaustion increases.There are two directions in determining the bearing capacity of these elements: calcul

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Randomised controlled trial of the Community Navigator programme to reduce loneliness and depression for adults with treatment-resistant depression in secondary community mental health services: trial protocol

Abstract Background New treatments are needed for people with treatment-resistant depression (TRD), who do not benefit from anti-depressants and many of whom do not recover fully with psychological treatments.The Community Navigator programme was co-produced with service users and practitioners.It is a novel social intervention which aims to reduce

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